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1

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice

Shemesh, Colby S., Yu, Rosie Z., Gaus, Hans J., Seth, Punit P., Swayze, Eric E., Bennett, Frank C., Geary, Richard S., Henry, Scott P., Wang, Yanfeng

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2016

Language:

english

File:

PDF, 806 KB

english, 2016

2

Molecular Diversity Analysis and Genetic Mapping of Pod Shatter Resistance Loci in Brassica carinata L.

Raman, Rosy, Qiu, Yu, Coombes, Neil, Song, Jie, Kilian, Andrzej, Raman, Harsh

Journal:

Frontiers in Plant Science

Year:

2017

Language:

english

File:

PDF, 2.00 MB

english, 2017

3

Hippocampal Place Cells Acquire Location-Specific Responses to the Conditioned Stimulus during Auditory Fear Conditioning

Marta A.P. Moita, Svetlana Rosis, Yu Zhou, Joseph E. LeDoux, Hugh T. Blair

Journal:

Year:

2003

Language:

english

File:

PDF, 410 KB

english, 2003

4

Immunogenicity Assessment of Inotersen, a 2â²- O -(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety

Yu, Rosie Z., Wang, Yanfeng, Norris, Dan A., Kim, Tae-Won, Narayanan, Padma, Geary, Richard S., Monia, Brett P., Henry, Scott P.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2020

File:

PDF, 588 KB

2020

5

Multi-environment QTL studies suggest a role for cysteine-rich protein kinase genes in quantitative resistance to blackleg disease in Brassica napus

Larkan, Nicholas J., Raman, Harsh, Lydiate, Derek J., Robinson, Stephen J., Yu, Fengqun, Barbulescu, Denise M., Raman, Rosy, Luckett, David J., Burton, Wayne, Wratten, Neil, Salisbury, Philip A., Rimm

Journal:

BMC Plant Biology

Year:

2016

Language:

english

File:

PDF, 1.52 MB

english, 2016

6

Nutrient supplements boost yeast transformation efficiency

Yu, Sheng-Chun, Dawson, Alexander, Henderson, Alyssa C., Lockyer, Eloise J., Read, Emily, Sritharan, Gayathri, Ryan, Marjah, Sgroi, Mara, Ngou, Pok M., Woodruff, Rosie, Zhang, Ruifeng, Ren Teen Chia,

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.23 MB

english, 2016

7

Clinical pharmacokinetics of second generation antisense oligonucleotides

Yu, Rosie Z, Grundy, John S, Geary, Richard S

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2013

Language:

english

File:

PDF, 571 KB

english, 2013

8

Genome-Wide Association Mapping Identifies Novel Loci for Quantitative Resistance to Blackleg Disease in Canola

Raman, Harsh, McVittie, Brett, Pirathiban, Ramethaa, Raman, Rosy, Zhang, Yuanyuan, Barbulescu, Denise M., Qiu, Yu, Liu, Shengyi, Cullis, Brian

Journal:

Frontiers in Plant Science

Year:

2020

File:

PDF, 3.39 MB

2020

9

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys

Yu, Rosie Z., Gunawan, Rudy, Post, Noah, Zanardi, Thomas, Hall, Shannon, Burkey, Jennifer, Kim, Tae-Won, Graham, Mark J., Prakash, Thazha P., Seth, Punit P., Swayze, Eric E., Geary, Richard S., Henry,

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2016

Language:

english

File:

PDF, 395 KB

english, 2016

10

Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

Zhang, Hong, Cook, Jesse, Nickel, Jeffrey, Yu, Rosie, Stecker, Kimberly, Myers, Kathleen, Dean, Nicholas M.

Journal:

Nature Biotechnology

Year:

2000

Language:

english

File:

PDF, 883 KB

english, 2000

11

Changes in Left Ventricular Diastolic Function of Asymptomatic Hereditary Hemochromatosis Subjects During Five Years of Follow-Up

Yukitaka Shizukuda, Dorothy J. Tripodi, Vandana Sachdev, Cynthia L. Brenneman, Stanislav Sidenko, Marilyn St. Peter, Charles D. Bolan, Yu Ying Yau, Susan F. Leitman, Myron A. Waclawiw, Douglas R. Rosi

Journal:

The American Journal of Cardiology

Year:

2011

Language:

english

File:

PDF, 165 KB

english, 2011

12

Population PharmacokineticâPharmacodynamic Modeling of Inotersen, an Antisense Oligonucleotide for Treatment of Patients with Hereditary Transthyretin Amyloidosis

Yu, Rosie Z., Collins, Jon W., Hall, Shannon, Ackermann, Elizabeth J., Geary, Richard S., Monia, Brett P., Henry, Scott P., Wang, Yanfeng

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2020

File:

PDF, 654 KB

2020

13

Phase 1 Investigation of a Ligand-Conjugated Antisense Oligonucleotide with Increased Potency for the Treatment of Transthyretin Amyloidosis

Viney, Nicholas J., Tai, Li-Jung, Jung, Shiangtung, Yu, Rosie Z., Guthrie, Spencer, Baker, Brenda F., Geary, Richard S., Schneider, Eugene, Guo, Shuling, Monia, Brett P.

Journal:

Journal of Cardiac Failure

Year:

2019

Language:

english

File:

PDF, 452 KB

english, 2019

14

Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100

Rosie Z. Yu, Kristina M. Lemonidis, Mark J. Graham, John E. Matson, Rosanne M. Crooke, Diane L. Tribble, Mark K. Wedel, Arthur A. Levin, Richard S. Geary

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 509 KB

english, 2009

15

Development of an Ultrasensitive Noncompetitive Hybridization–Ligation Enzyme-Linked Immunosorbent Assay for the Determination of Phosphorothioate Oligodeoxynucleotide in Plasma

Rosie Z. Yu, Brenda Baker, Alfred Chappell, Richard S. Geary, Ellen Cheung, Arthur A. Levin

Journal:

Analytical Biochemistry

Year:

2002

Language:

english

File:

PDF, 208 KB

english, 2002

16

Local and systemic tolerability of a 2′O-methoxyethyl antisense oligonucleotide targeting interleukin-4 receptor-α delivery by inhalation in mouse and monkey

Fey, Robert A., Templin, Michael V., McDonald, Jacob D., Yu, Rosie Z., Hutt, Julie A., Gigliotti, Andrew P., Henry, Scott P., Reed, Matthew D.

Journal:

Inhalation Toxicology

Year:

2014

Language:

english

File:

PDF, 285 KB

english, 2014

17

381 ABERRANT EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASE 5 (ERK5) SIGNALLING PROMOTES CELLULAR MOTILITY AND INVASION IN PROSTATE CARCINOGENESIS

Ramsay, Alison, McCracken, Stuart, Morland, Rosie, Fleming, Janis, Machesky, Laura, Yu, Xinzi, Edwards, Dylan, Nuttall, Robert, Seywright, Morag, Keller, Evan, Leung, Hing

Journal:

The Journal of Urology

Year:

2010

Language:

english

File:

PDF, 111 KB

english, 2010

18

PRINCIPLES OF GRAVITATIONAL WAVES DETECTION THROUGH ATOM INTERFEROMETRY

VETRANO, FLAVIO, GUIDI, GIANLUCA M., VICERÉ, ANDREA, BODART, QUENTIN, LIEN, YU-HUNG, PREVEDELLI, MARCO, ROSI, GABRIELE, SORRENTINO, FIODOR, TINO, GUGLIELMO M.

Journal:

International Journal of Modern Physics Conference Series

Year:

2013

Language:

english

File:

PDF, 858 KB

english, 2013

19

A Major Locus for Manganese Tolerance Maps on Chromosome A09 in a Doubled Haploid Population of Brassica napus L.

Raman, Harsh, Raman, Rosy, McVittie, Brett, Orchard, Beverley, Qiu, Yu, Delourme, Regine

Journal:

Frontiers in Plant Science

Year:

2017

Language:

english

File:

PDF, 1.72 MB

english, 2017

20

A Randomized, Double-Masked, Placebo-Controlled Study of Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule 1, for the Treatment of Subjects With Active Crohn’s Disease

Yacyshyn, Bruce, Chey, William Y., Wedel, Mark K., Yu, Rosie Z., Paul, David, Chuang, Emil

Journal:

Clinical Gastroenterology and Hepatology

Year:

2007

Language:

english

File:

PDF, 572 KB

english, 2007

21

In Vitro Metabolic Stabilities and Metabolism of 2′- O -(Methoxyethyl) Partially Modified Phosphorothioate Antisense Oligonucleotides in Preincubated Rat or Human Whole Liver Homogenates

Baek, Min-Son, Yu, Rosie Z., Gaus, Hans, Grundy, John S., Geary, Richard S.

Journal:

Oligonucleotides

Year:

2010

Language:

english

File:

PDF, 344 KB

english, 2010

22

Lack of Interactions Between an Antisense Oligonucleotide with 2′- O -(2-Methoxyethyl) Modifications and Major Drug Transporters

Yu, Rosie Z., Warren, Mark S., Watanabe, Tanya, Nichols, Brandon, Jahic, Mirza, Huang, Jane, Burkey, Jennifer, Geary, Richard S., Henry, Scott P., Wang, Yanfeng

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2016

Language:

english

File:

PDF, 218 KB

english, 2016

23

Development of an ion-pair reverse-phase liquid chromatographic/tandem mass spectrometry method for the determination of an 18-mer phosphorothioate oligonucleotide in mouse liver tissue

Murphy, Anthony, Brown-Augsburger, Patricia, Yu, Rosie, Geary, Richard, Thibodeaux, Stefan, Ackermann, Bradley

Journal:

European Journal of Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 268 KB

english, 2005

24

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc 3 -Conjugated 2′-MOE-ASOs

Shemesh, Colby S., Yu, Rosie Z., Warren, Mark S., Liu, Michael, Jahic, Mirza, Nichols, Brandon, Post, Noah, Lin, Song, Norris, Daniel A., Hurh, Eunju, Huang, Jane, Watanabe, Tanya, Henry, Scott P., Wa

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 1.62 MB

english, 2017

25

Integrated Assessment of the Clinical Performance of GalNAc 3 -Conjugated 2′- O -Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience

Crooke, Stanley T., Baker, Brenda F., Xia, Shuting, Yu, Rosie Z., Viney, Nicholas J., Wang, Yanfeng, Tsimikas, Sotirios, Geary, Richard S.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2018

Language:

english

File:

PDF, 1.78 MB

english, 2018

26

Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism

Yu Xia, H. A. Rohan de Silva, Barbara L. Rosi, Larry H. Yamaoka, Jacqueline B. Rimmler, Margaret A. Pericak-Vance, Allen D. Roses, Xiaohua Chen, Eliezer Masliah, Richard Deteresa, Akihiko Iwai, Mary S

Journal:

Annals of Neurology

Year:

1996

Language:

english

File:

PDF, 875 KB

english, 1996

27

Total Structure Determination of Au16(S-Adm)12 and Cd1Au14(StBu)12 and Implications for the Structure of Au15(SR)13

Yang, Sha, Chen, Shuang, Xiong, Lin, Liu, Chong, Yu, Haizhu, Wang, Shuxin, Rosi, Nathaniel L, Pei, Yong, Zhu, Manzhou

Journal:

Journal of the American Chemical Society

Year:

2018

Language:

english

File:

PDF, 836 KB

english, 2018

28

312 Treatment of chronic hepatitis C with ISIS 14803, an antisense inhibitor of HCV, given for 12 weeks

Stuart C. Gordon, Bruce R. Bacon, Ira M. Jacobson, Mitchell L. Shiffman, Nezam H. Afdhal, Rosie Z. Yu, John G. McHutchison, Jesse Kwoh

Journal:

Year:

2003

Language:

english

File:

PDF, 267 KB

english, 2003

29

Prediction of Clinical Responses in a Simulated Phase III Trial of Crohn's Patients Administered the Antisense Phosphorothioate Oligonucleotide ISIS 2302: Comparison of Proposed Dosing Regimens

Yu, Rosie Z., Su, John Q., Grundy, John S., Geary, Richard S., Sewell, K. Lea, Dorr, Andrew, Levin, Arthur A.

Journal:

Antisense and Nucleic Acid Drug Development

Year:

2003

Language:

english

File:

PDF, 177 KB

english, 2003

30

Pharmacokinetics and Tissue Disposition in Monkeys of an Antisense Oligonucleotide Inhibitor of Ha-Ras Encapsulated in Stealth Liposomes

Rosie Z. Yu, Richard S. Geary, Janet M. Leeds, Tanya Watanabe, Jonathon R. Fitchett, John E. Matson, Rahul Mehta, Gregory R. Hardee, Michael V. Templin, Ken Huang, Mary S. Newman, Yoli Quinn, Paul Ust

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.30 MB

1999

31

Phase I Clinical/Pharmacokinetic and Pharmacodynamic Trial of the c- raf -1 Antisense Oligonucleotide ISIS 5132 (CGP 69846A)

Stevenson, James P., Yao, Kang-Shen, Gallagher, Maryann, Friedland, David, Mitchell, Edith P., Cassella, Amy, Monia, Brett, Kwoh, T. Jesse, Yu, Rosie, Holmlund, Jon, Dorr, F. Andrew, O'Dwyer, Peter J.

Journal:

Journal of Clinical Oncology

Year:

1999

Language:

english

File:

PDF, 109 KB

english, 1999

32

Effects of human and murine antisense oligonucleotide inhibitors of ICAM-1 on reproductive performance, fetal development, and post-natal development in mice

Scott P. Henry, Kevin H. Denny, Mike V. Templin, Rosie Z. Yu, Arthur A. Levin

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Year:

2004

Language:

english

File:

PDF, 108 KB

english, 2004

33

Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs

Araz A Raoof, Zeibun Ramtoola, Brain McKenna, Rosie Z Yu, Greg Hardee, Richard S Geary

Journal:

European Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 658 KB

english, 2002

34

A phase I trial of an antisense inhibitor of hepatitis C virus (ISIS 14803), administered to chronic hepatitis C patients

John G. McHutchison, Keyur Patel, Paul Pockros, Lisa Nyberg, Stephen Pianko, Rosie Z. Yu, F. Andrew Dorr, T. Jesse Kwoh

Journal:

Journal of Hepatology

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

35

Metabolism and Disposition of Volanesorsen, a 2â²- O -(2 methoxyethyl) Antisense Oligonucleotide, Across Species

Post, Noah, Yu, Rosie, Greenlee, Sarah, Gaus, Hans, Hurh, Eunju, Matson, John, Wang, Yanfeng

Journal:

Drug Metabolism and Disposition

Year:

2019

File:

PDF, 945 KB

2019

36

Effects of an antisense oligonucleotide inhibitor of human ICAM-1 on fetal development in rabbits

Scott P. Henry, Kevin H. Denny, Mike V. Templin, Rosie Z. Yu, Arthur A. Levin

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Year:

2004

Language:

english

File:

PDF, 98 KB

english, 2004

37

Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc 3 -Conjugated Antisense Oligonucleotides

Wang, Yanfeng, Yu, Rosie Z., Henry, Scott, Geary, Richard S.

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2019

Language:

english

File:

PDF, 1.46 MB

english, 2019

38

GWAS hints at pleiotropic roles for FLOWERING LOCUS T in flowering time and yield-related traits in canola

Raman, Harsh, Raman, Rosy, Qiu, Yu, Yadav, Avilash Singh, Sureshkumar, Sridevi, Borg, Lauren, Rohan, Maheswaran, Wheeler, David, Owen, Oliver, Menz, Ian, Balasubramanian, Sureshkumar

Journal:

Year:

2019

Language:

english

File:

PDF, 2.57 MB

english, 2019

39

Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey

Rosie Z. Yu, Richard S. Geary, Janet M. Leeds, Tanya Watanabe, Max Moore, Jon Fitchett, John Matson, Todd Burckin, Michael V. Templin, Arthur A. Levin

Journal:

Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 238 KB

english, 2001

40

Suppressing transthyretin production in mice, monkeys and humans using 2nd-Generation antisense oligonucleotides

Ackermann, Elizabeth J., Guo, Shuling, Benson, Merrill D., Booten, Sheri, Freier, Sue, Hughes, Steven G., Kim, Tae-Won, Jesse Kwoh, T., Matson, John, Norris, Dan, Yu, Rosie, Watt, Andy, Monia, Brett P

Journal:

Year:

2016

Language:

english

File:

PDF, 835 KB

english, 2016

41

Single Ligand Exchange on an Au-Cu Bimetal Nanocluster and Mechanism

Song, Yongbo, Lv, Ying, Zhou, Meng, Luo, Tian-Yi, Zhao, Shuo, Rosi, Nathaniel L., Yu, Haizhu, Zhu, Manzhou, Jin, Rongchao

Journal:

Year:

2018

Language:

english

File:

PDF, 1.15 MB

english, 2018

42

Bibliometric analysis of cardiometabolic disorders studies involving NO2, PM2.5 and noise exposure

Huang, Yu-Kai, Hanneke, Rosie, Jones, Rachael M.

Journal:

BMC Public Health

Year:

2019

Language:

english

File:

PDF, 1.35 MB

english, 2019

43

Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice

Yu, Rosie Z, Graham, Mark J, Post, Noah, Riney, Stan, Zanardi, Thomas, Hall, Shannon, Burkey, Jennifer, Shemesh, Colby S, Prakash, Thazha P, Seth, Punit P, Swayze, Eric E, Geary, Richard S, Wang, Yanf

Journal:

Molecular Therapy — Nucleic Acids

Year:

2016

Language:

english

File:

PDF, 690 KB

english, 2016

44

Transient Corpus Callosal Lesion presenting with Alien Hand Syndrome

Gellman, S. Rosie, Ng, Yu-Tze

Journal:

Pediatric Neurology

Year:

2018

Language:

english

File:

PDF, 313 KB

english, 2018

45

A review of the 10/66 dementia research group

Prina, A. Matthew, Mayston, Rosie, Wu, Yu-Tzu, Prince, Martin

Journal:

Social Psychiatry and Psychiatric Epidemiology

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

46

Effect of Mipomersen, an Apolipoprotein B Synthesis Inhibitor, on Low-Density Lipoprotein Cholesterol in Patients With Familial Hypercholesterolemia

Fatima Akdim, Maartje E. Visser, Diane L. Tribble, Brenda F. Baker, Erik S.G. Stroes, Rosie Yu, Joann D. Flaim, John Su, Evan A. Stein, John J.P. Kastelein

Journal:

The American Journal of Cardiology

Year:

2010

Language:

english

File:

PDF, 355 KB

english, 2010

47

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

Geary, Richard S., Norris, Daniel, Yu, Rosie, Bennett, C. Frank

Journal:

Advanced Drug Delivery Reviews

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

48

Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes

Digenio, Andres, Dunbar, Richard L., Alexander, Veronica J., Hompesch, Marcus, Morrow, Linda, Lee, Richard G., Graham, Mark J., Hughes, Steven G., Yu, Rosie, Singleton, Walter, Baker, Brenda F., Bhano

Journal:

Year:

2016

Language:

english

File:

PDF, 986 KB

english, 2016

49

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys

Shemesh, Colby S, Yu, Rosie Z, Gaus, Hans J, Greenlee, Sarah, Post, Noah, Schmidt, Karsten, Migawa, Michael T, Seth, Punit P, Zanardi, Thomas A, Prakash, Thazha P, Swayze, Eric E, Henry, Scott P, Wang

Journal:

Molecular Therapy — Nucleic Acids

Year:

2016

Language:

english

File:

PDF, 4.02 MB

english, 2016

50

Tissue disposition of 2′-O-(2-methoxy) ethyl modified antisense oligonucleotides in monkeys

Rosie Z. Yu, Richard S. Geary, David K. Monteith, John Matson, Loanne Truong, Jon Fitchett, Arthur A. Levin

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 160 KB

english, 2004

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